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KMID : 0378019890320110065
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New Medical Journal
1989 Volume.32 No. 11 p.65 ~ p.69
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Clinical Evaluation of Neuromuscular Blockade in Man Produced by Combinations of Vecuronium and d-Tubocurarine for Endotracheal Intubation
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Abstract
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The individual onset of action of vecuronium and d-tubocurarine has been examined with a priming dose of same or the other agent.
Measurement of changes in the T1% of TOF ratio of the adductor pollicis muscle were performed by Accelograph ( Biometer) .
Sixty adult patients were administered vecuronium 0.015mg / kg (group 1 and 4), d-tubocurarine 0.09mg / kg (group 2 and 3) as a priming agents.
After 5 minutes later, the intubating dose of vecuronium 0.085mg / kg (group 1 and 2), d-tubocurarine 0.51mg / kg(group 3 and 4) were administered with the induction agent, thiopental sodium 5mg / kg.
All sixty patients underwent orotracheal intubation at 60 seconds after the iniection of intubation dose.
Incidence of patient complaints after priming doses, T1% at 5 minutes following tie priming dose and 60 seconds following the intubating dose, blood pressure and heart rate after intubation were evaluated.
The results are as follows:
1) After the priming dose, forty-eight patients complained of minor side effects. 2) There was no difficulty in intubation.
3) T1% at intubation were 15.0+2.0%(group 1), 11.9+2.9%(group 2), 10.9+3.1%(group 3) and 7.5+2.9%(group 4).
4) In group 3 and 4, blood pressure was decreased significantly (p<0.05). 5) In group 1, 3 and 4, heart rate was increased significantly (p<0.05).
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